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 About:
Mechanism of action

CAMZYOS®▼ (mavacamten) is the first and only licensed selective, allosteric and reversible cardiac myosin inhibitor for symptomatic NYHA class II and III obstructive HCM.1

CAMZYOS (mavacamten) is the only licensed non-invasive oral therapy that targets the underlying pathophysiology of obstructive HCM by reducing excess formation of myosin-actin cross bridging.1–3

CAMZYOS (mavacamten) modulates the number of myosin heads that can enter power-generating states, thus reducing the probability of force-producing systolic and residual diastolic cross-bridge formation.1

 

Inside the obstructive HCM sarcomere with and without CAMZYOS (mavacamten)2,3

Normalises contractility

Adapted from Desai MY et al. 2022.3

Cardiac myosin inhibition with CAMZYOS (mavacamten):1

Normalises contractility

Normalises contractility

Reduces dynamic LVOT obstruction

Reduces dynamic LVOT obstruction

Improves cardiac filling pressures

Improves cardiac filling pressures

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HCM, hypertrophic cardiomyopathy; LVOT, left ventricular outflow tract; NYHA, New York Heart Association.

References
  1. CAMZYOS (mavacamten) Summary of Product Characteristics. 
  2. Olivotto I et al. Lancet. 2020;396(10253):759–769. 
  3. Desai MY et al. J Am Coll Cardiol. 2022;80(2):95–108.